Biobank genomics
Run GWAS and build polygenic risk scores on a large biobank, with the clinical data in the same place.
How it works
1. Build the cohort from the biobank's clinical records, including whether genomic data is available for each participant.
2. Add genotypes and polygenic risk scores to the dataset, from array, exome or genome data.
3. Run a GWAS with quality control, or test risk scores and genotypes with the statistics and machine learning modules.
Published work
UK Biobank-Based Genetic and Proteomic Network Insights into Metabolic Dysfunction-Associated Steatotic Liver Disease Pathogenesis
Kang SW, Kim SK, Ban JY, Park MS. Int J Mol Sci, Apr 2026.
GWAS performed using the COMPASS platform.